Publications on Metallodrugs | Laboratory of Bioinorganic Chemistry, NUS

W. H. Ang, Platinum(IV) anticancer complex with novel modes of activity, Curr. Op. Med. Chem. 2010, submitted.
W. H. Ang, MyatNoeZin Myint, S. J. Lippard, Transcription Inhibition by Platinum DNA Cross-links in Live Mammalian Cells, J. Am. Chem. Soc. 2010, 132, 7429-7435.
W. H. Ang, S. J. Lippard, Functional consequence of plasmid DNA modified site-specifically with 7-deaza-deoxyadenosine at a single, programmable site, Chem. Commun. 2009, 5820-5822.
W. H. Ang, W. W. Brown, S. J. Lippard, Preparation of platinated mammalian expression vectors incorporating site-specifically platinated-DNA lesions, Bioconjugate Chem. 2009, 20, 1058-1063.
W. H. Ang, L. J. Parker, A. De Luca, L. Juillerat-Jeanneret, C. J. Morton, M. Lo Bello, M. W. Parker, Paul J. Dyson, Rational design of an organometallic glutathione transferase inhibitor and its interaction with GST P1-1, Angew. Chem. Int. Ed. Engl. 2009, 48, 3854-3857.
W. H. Ang, Z. Grote, R. Scopelliti, L. Juillerat-Jeanneret, K. Severin, P. J. Dyson, Organometallic complexes that interconvert between trimeric and monomeric structures as a function of pH and their effect on human cancer and fibroblast cells, J. Organomet. Chem. 2009, 694, 968-972.
A. Mathieu, B. Therrien, G. Süss-Fink, P. Stepnicka, W. H. Ang, P. J. Dyson, Ferrocenoyl Pyridine Arene Ruthenium Complexes with Anticancer Properties: Synthesis, Structure, Electrochemistry, and Cytotoxicity, Inorg. Chem. 2008, 47, 578-583.
F. Schmitt, P. Govindaswamy, G. Süss-Fink, W. H. Ang, P. J. Dyson, L. Juillerat-Jeanneret, B. Therrien, Ruthenium-porphyrin compounds for photodynamic therapy of cancer, J. Med. Chem. 2008, 51, 1811-1816.
W. H. Ang, A. De Luca, C. Chapuis-Bernasconi, L. Juillerat-Jeanneret, M. Lo Bello, P. J. Dyson, Organometallic ruthenium inhibitors of glutathione-S-transferase P1-1 as anticancer drugs, ChemMedChem 2007, 2, 1799-1806.
B. Therrien, W. H. Ang, F. Chérioux, L. Vieille-Petit, L. Juillerat-Jeanneret, G. Süss-Fink, P. J. Dyson, Remarkable anticancer activity of triruthenium-arene clusters compared to tetraruthenium-arene clusters, J. Cluster Sci. 2007, 18, 741-752.
A. Casini, G. Mastrobuoni, W. H. Ang, C. Gabbiani, G. Pieraccini, G. Moneti, P. J. Dyson, L. Messori, ESI-MS characterization of protein adducts of anticancer ruthenium(II)-arene PTA (RAPTA) complexes, ChemMedChem 2007, 2, 631-635.
C. Hartinger, W. H. Ang, A. Casini, L. Messori, B. K. Keppler, P. J. Dyson, Mass spectrometric analysis of ubiquitin-platinum complex interaction in leading anticancer drugs: MALDI versus ESI, J. Anal. At. Spec. 2007, 22, 960-967.
W. H. Ang, E. Daldini, L. Juillerat-Jeanneret, P. J. Dyson, Strategy to tether organometallic ruthenium-arene anti-cancer compounds to recombinant human serum albumin, Inorg. Chem. 2007, 46, 9048-9050.
W. H. Ang, Development of organometallic ruthenium(II) anticancer (RAPTA) drugs (invited paper), Chimia 2007, 61, 140-142.
C. A. Vock, W. H. Ang, C. Scolaro, L. Juillerat-Jeanneret, G. Sava, P. J. Dyson, Synthesis, characterisation and in vitro evaluation of novel ruthenium(II) η⁶-arene complexes with MDR modulators as ligands, J. Med. Chem. 2007, 50, 2166 -2175.
W. H. Ang, P. J. Dyson, Classical and non-classical ruthenium-based anticancer drugs: towards targeted chemotherapy (review), Eur. J. Inorg. Chem. 2006, 20, 4003-4018.
A. Dorcier, W. H. Ang, S. Bolaño, L. Gonsalvi, L. Juillerat-Jeannerat, G. Laurenczy, M. Peruzzini, A. D. Phillips, F. Zanobini, P. J. Dyson, In vitro evaluation of rhodium and osmium RAPTA analogues: the case for organometallic anticancer drugs not based on ruthenium, Organometallics 2006, 25, 4090-4096.
W. H. Ang, E. Daldini, C. Scolaro, R. Scopelliti, L. Juillerat-Jeanneret, P. J. Dyson, Development of ruthenium arene anticancer drugs that resist hydrolysis, Inorg. Chem. 2006, 45, 9006-9013.
W. H. Ang, S. Pilet, R. Scopelliti, F. Bussy, L. Juillerat-Jeanneret, P. J. Dyson, Synthesis and characterization of platinum(IV) anticancer drugs with functionalized aromatic carboxylate ligands: Influence of the ligands on drug efficacies and uptake, J. Med Chem. 2005, 48, 8060-8069.
W. H. Ang, I. Khalaila, C. S. Allardyce, L. Juillerat-Jeanneret, P. J. Dyson, Rational design of platinum(IV) compounds to overcome glutathione-S-transferase mediated drug resistance, J. Am. Chem. Soc. 2005, 127, 1382-1383.